Transcriptional Changes in Gene Expression
Individual differences in the rate of aging are dictated by the ability with which a life form changes assets into metabolic energy consequently keeping up the homeostatic state of its cells and tissues. This observation has been incorporated with logical investigations of the metabolic procedure to infer the accompanying rule: The metabolic strength of administrative systems, that is the capacity of cells to keep up stable centralizations of Reactive Oxygen Species (ROS) and other basic metabolites is the prime determinant of life expectancy. The metabolic steadiness of an administrative system is dictated by the decent variety of the metabolic pathways or the level of availability of qualities in the system. These properties can be exactly assessed as far as transcriptional changes in quality gene expression. We utilize microarrays to explore the age-reliance of transcriptional changes of qualities in the insulin signalling, oxidative phosphorylation and glutathione metabolism pathways in mice. Our examinations portray age and tissue particular examples of transcriptional changes which are steady with the metabolic stability–longevity principle. This examination, what's more, rejects the free radical theory which proposes that the generation rate of ROS, and not its stability, determines life span.
- Brain aging-endothelial cortex, superior frontal gyros
- Meta-analysis study in aging
- Transcriptional signature of aging
- Dynamic RNA modifications in aging
- Reactive Oxygen Species (ROS)
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