Cellular Senescence and Apoptosis
Cells constantly encounter stress and damage from exogenous and endogenous sources, and their reactions range from complete recovery to cell death. Multiplying cells can start an extra reaction by embracing a condition of permanent cell-cycle capture that is named cell senescence. Understanding the causes and outcomes of cell senescence has given novel experiences into how cells respond to pressure, particularly genotoxic stress, and how this cell reaction can influence complex organismal procedures, for example, the advancement of cancer and ageing. Cell senescence may likewise advance tissue repair and fuel irritation related with aging and cancer progression. In this manner, cell senescence may take an interest in four complex natural procedures (tumour suppression, tumour promotion, aging, and tissue repair), some of which have clearly contradicting impacts. The test now is to comprehend the senescence reaction all around harness its advantages while stifling its disadvantages
- Replicative senescence
- DNA damage induced senescence
- Change in fluidity and permeability of plasma membrane
- Change in fluidity and permeability of plasma membrane
- Decrease in granular endoplasmic reticulum
- Degeneration of chloroplast
- Mutation in mitochondrial DNA
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